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Abstract
Originally Published 1 January 1986
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Induction of increased collagen and elastin biosynthesis in copper-deficient pig aorta.

Arteriosclerosis: An Official Journal of the American Heart Association, Inc.

Abstract

Young pigs raised on a copper-deficient diet develop severe abnormalities of connective tissue due to defective cross-linking of collagen and elastin. They eventually succumb to anemia and cardiovascular damage, the latter apparently due to the defective connective tissue metabolism. We evaluated the effects of nutritional copper deficiency upon collagen and elastin synthesis using short-term explant cultures of the medial portion of four successive segments of the descending aorta from 110-day-old pigs raised on a copper-deficient diet. Collagen synthesis was evaluated by collagenase susceptibility, and elastin synthesis was quantified by immunoprecipitation with an antiporcine-elastin antiserum. In the normal developing aorta, elastin synthesis was maximal in the upper thoracic aorta, while levels of collagen synthesis were highest in the lower abdominal aorta. Both activities subsided by 110 days postpartum. Compared with controls, the copper-deficient group showed: 1) histopathologic changes confined to the luminal half of the thoracic aorta; 2) a 1.3- to 1.6-fold increase in cellularity along the entire length of the organ; 3) a 1.3- to 2.4-fold increase in relative collagen synthesis, the greatest change occurring in the thoracic portion; 4) a 3- to 4-fold increase of relative elastin synthesis in the thoracic aorta, the abdominal aorta remaining unchanged; 5) 4- to 10-fold increases in collagen production; and 6) a greater than 15-fold increase in elastin production by the tissue of the thoracic aorta.(ABSTRACT TRUNCATED AT 250 WORDS)

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Go to Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Go to Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Pages: 98 - 104
PubMed: 3942564

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Published online: 1 January 1986
Published in print: January 1986

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  1. Sudden death due to aortic rupture in New Zealand sheep, New Zealand Veterinary Journal, 73, 1, (53-59), (2024).https://doi.org/10.1080/00480169.2024.2403459
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  2. Evaluation of the Efficacy of an Elastin-Inducing Composition Containing Amino Acids, Copper, and Hyaluronic Acid: Results of an Open Single-Center Clinical Trial Study, Cosmetics, 9, 3, (51), (2022).https://doi.org/10.3390/cosmetics9030051
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  3. Novel Assessment of Collagen and Its Crosslink Content in the Humerus from Primiparous Dairy Cows with Spontaneous Humeral Fractures Due to Osteoporosis from New Zealand, Biology, 11, 10, (1387), (2022).https://doi.org/10.3390/biology11101387
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  4. Low copper levels measured in the aortic wall of New Zealand patients with non-syndromic ascending thoracic aortic aneurysm, Interactive CardioVascular and Thoracic Surgery, 35, 4, (2022).https://doi.org/10.1093/icvts/ivac235
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  5. Reactive magnetron co-sputtering of Ti-xCuO coatings: Multifunctional interfaces for blood-contacting devices, Materials Science and Engineering: C, 116, (111198), (2020).https://doi.org/10.1016/j.msec.2020.111198
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  6. Ruptured hepatic artery aneurysm in a domestic yak, Journal of Veterinary Diagnostic Investigation, 31, 1, (74-77), (2018).https://doi.org/10.1177/1040638718811400
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  7. Therapeutic Potential of Copper Chelation with Triethylenetetramine in Managing Diabetes Mellitus and Alzheimerʼs Disease, Drugs, 71, 10, (1281-1320), (2011).https://doi.org/10.2165/11591370-000000000-00000
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  8. Influence of copper on early development: Prenatal and postnatal considerations, BioFactors, 36, 2, (136-152), (2010).https://doi.org/10.1002/biof.85
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  9. Increased Elastin mRNA Levels Associated with Surgically Induced Intimal Injury, Connective Tissue Research, 18, 2, (65-78), (2009).https://doi.org/10.3109/03008208809008059
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  10. Chapter 6 Inorganic feed additives, Biology of Nutrition in Growing Animals, (179-249), (2006).https://doi.org/10.1016/S1877-1823(09)70093-1
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  11. See more
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Induction of increased collagen and elastin biosynthesis in copper-deficient pig aorta.
Arteriosclerosis, Thrombosis, and Vascular Biology
  • Vol. 6
  • No. 1

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