Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients.
Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Abstract
The aim of this study was to determine the extent of accumulation of lipoprotein(a) [Lp(a)] in human arterial wall and to define its potential role in atherogenesis. Biopsies routinely taken from the ascending aorta of 107 patients undergoing aortocoronary bypass surgery were analyzed for lipid and lipoprotein parameters, which were then correlated to serum values. A significant positive correlation was established between serum Lp(a) and arterial wall apolipoprotein (apo)(a) by enzyme-linked immunosorbent assay. High serum Lp(a) also led to a significant increase of apo B in the arterial wall. No significant correlation was found between apo B in serum and aortic tissue. Apo B was found to be partially linked to apo(a) in the aortic extract. Furthermore, apo(a) was found to be intact, as determined by its molecular weight in sodium dodecyl sulfate electrophoresis. This technique also revealed that the apo(a) isoform pattern of aortic homogenate was comparable to the individual serum pattern. Immunohistochemical methods demonstrated a striking colocalization of apo(a) and apo B in the arterial wall, predominantly located extracellularly. Both proteins were increased in atherosclerotic plaques. With density gradient ultracentrifugation, Lp(a)-like particles could be isolated from plaque tissue. This initial study showed that Lp(a) accumulates in the arterial wall, partly in the form of lipoprotein-like particles, therefore contributing to plaque formation and coronary heart disease.
Formats available
You can view the full content in the following formats:
Information & Authors
Information
Published In
Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Pages: 579 - 592
PubMed: 2528948
Copyright
Copyright © 1989 by American Heart Association.
History
Published in print: January 1989
Published online: 1 September 1989
Authors
Metrics & Citations
Metrics
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.
- Development of a fully automated latex-enhanced immunoturbidimetric method for quantitative serum Lp(a) measurement, Biotechnology Letters, 47, 2, (2025).https://doi.org/10.1007/s10529-025-03564-w
- LP(a): The new marker of high cardiovascular risk, Nutrition, Metabolism and Cardiovascular Diseases, 35, 3, (103845), (2025).https://doi.org/10.1016/j.numecd.2024.103845
- Lipoprotein(a) and cardiovascular disease, Biochemical Journal, 481, 19, (1277-1296), (2024).https://doi.org/10.1042/BCJ20240037
- The levels of serum lipoprotein(a) on clinical outcomes in Chinese hospitalized patients with cardiovascular diseases, European Journal of Medical Research, 29, 1, (2024).https://doi.org/10.1186/s40001-024-01957-7
- Genetics and Pathophysiological Mechanisms of Lipoprotein(a)‐Associated Cardiovascular Risk, Journal of the American Heart Association, 13, 12, (2024)./doi/10.1161/JAHA.123.033654
- High lipoprotein(a): Actionable strategies for risk assessment and mitigation, American Journal of Preventive Cardiology, 18, (100651), (2024).https://doi.org/10.1016/j.ajpc.2024.100651
- Lipoprotein(a) and Atherosclerotic Cardiovascular Disease: Where Do We Stand?, International Journal of Molecular Sciences, 25, 6, (3537), (2024).https://doi.org/10.3390/ijms25063537
- Is inverse association between lipoprotein(a) and diabetes mellitus another paradox in cardiometabolic medicine?, Expert Review of Endocrinology & Metabolism, 19, 1, (63-70), (2023).https://doi.org/10.1080/17446651.2023.2293108
- Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives, International Journal of Environmental Research and Public Health, 20, 18, (6721), (2023).https://doi.org/10.3390/ijerph20186721
- Molecular Mechanisms of Lipoprotein(a) Pathogenicity: Tantalizing Clues and Unanswered Questions, Lipoprotein(a), (173-187), (2023).https://doi.org/10.1007/978-3-031-24575-6_10
- See more
Loading...
View Options
Login options
Check if you have access through your login credentials or your institution to get full access on this article.
Personal login Institutional LoginPurchase Options
Purchase this article to access the full text.
eLetters(0)
eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.
Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.