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Letter
Originally Published 3 February 2025

Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study

Stephen O. Brennan, MB https://orcid.org/0000-0002-3224-1621 [email protected], Peter J. Kelly, MD https://orcid.org/0000-0003-4772-6565, Sarah Gorey, MB https://orcid.org/0000-0001-8079-7969, Pádraig Synnott, MB, Dipender Gill, BMBCh, PhD https://orcid.org/0000-0001-7312-7078, Martin Dichgans, MD https://orcid.org/0000-0002-0654-387X, Marios K. Georgakis, PhD https://orcid.org/0000-0003-3507-3659, … Show All … , Marie-Joe Dib, PhD https://orcid.org/0000-0001-7591-5684, Eloi Gagnon, MA https://orcid.org/0000-0002-7483-1371, Niall Mahon, MB https://orcid.org/0000-0002-2872-2297, Gavin J. Blake, MB, Christina Jern, PhD https://orcid.org/0000-0002-7531-2354, Hugh S. Markus, PhD https://orcid.org/0000-0002-9794-5996, William Whiteley, PhD https://orcid.org/0000-0002-4816-8991, and John J. McCabe, PhD https://orcid.org/0000-0003-2029-1303Author Info & Affiliations
Circulation
Volume 151, Number 5
https://doi.org/10.1161/CIRCULATIONAHA.124.072238
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REFERENCES

1.
Jia X, Buckley L, Sun C, Al Rifai M, Yu B, Nambi V, Virani SS, Selvin E, Matsushita K, Hoogeveen RC, et al. Association of interleukin-6 and interleukin-18 with cardiovascular disease in older adults: Atherosclerosis Risk in Communities study. Eur J Prev Cardiol. 2023;30:1731–1740. doi: 10.1093/eurjpc/zwad197
Crossref
PubMed
Google Scholar
2.
Henry A, Gordillo-Marañón M, Finan C, Schmidt AF, Ferreira JP, Karra R, Sundström J, Lind L, Ärnlöv J, Zannad F, et al; HERMES and SCALLOP Consortia. Therapeutic targets for heart failure identified using proteomics and mendelian randomization. Circulation. 2022;145:1205–1217. doi: 10.1161/CIRCULATIONAHA.121.056663
Crossref
PubMed
Google Scholar
3.
Jefferis BJ, Papacosta O, Owen CG, Wannamethee SG, Humphries SE, Woodward M, Lennon LT, Thomson A, Welsh P, Rumley A, et al. Interleukin 18 and coronary heart disease: prospective study and systematic review. Atherosclerosis. 2011;217:227–233. doi: 10.1016/j.atherosclerosis.2011.03.015
Crossref
PubMed
Google Scholar
4.
O’Brien LC, Mezzaroma E, Van Tassell BW, Marchetti C, Carbone S, Abbate A, Toldo S. Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure. Mol Med. 2014;20:221–229. doi: 10.2119/molmed.2014.00034
Crossref
PubMed
Google Scholar
5.
Brennan S, Kelly PJ, Gorey S, Synnott P, Gill D, Dichgans M, Georgakis M, Dib M, Gagnon E, Mahon N, et al. Genetically predicted IL-18 inhibition and risk of cardiovascular events: a mendelian randomization study. Preprint posted online July 3, 2024. medRxiv. doi: 10.1101/2024.07.01.24309808
Crossref
Google Scholar

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Information & Authors

Information

Published In

Go to Circulation
Go to Circulation
Circulation
Volume 151 • Number 5 • 4 February 2025
Pages: 334 - 336
PubMed: 39899632

Copyright

© 2025 American Heart Association, Inc.

History

Published online: 3 February 2025
Published in print: 4 February 2025

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Keywords

  1. cardiovascular diseases
  2. genetics
  3. interleukin-18

Authors

Affiliations

Stephen O. Brennan, MB https://orcid.org/0000-0002-3224-1621 [email protected]
Departments of Neurology (S.O.B., P.J.K.), Mater Misericordiae University Hospital, Dublin, Ireland.
School of Medicine, University of Galway, Ireland (S.O.B.).
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Peter J. Kelly, MD https://orcid.org/0000-0003-4772-6565
Departments of Neurology (S.O.B., P.J.K.), Mater Misericordiae University Hospital, Dublin, Ireland.
Health Research Board, Stroke Clinical Trials Network Ireland, Dublin, Ireland (P.J.K., S.G., P.S., J.J.M.).
School of Medicine, University College Dublin, Ireland (P.J.K., J.J.M.).
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Sarah Gorey, MB https://orcid.org/0000-0001-8079-7969
Health Research Board, Stroke Clinical Trials Network Ireland, Dublin, Ireland (P.J.K., S.G., P.S., J.J.M.).
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Pádraig Synnott, MB
Health Research Board, Stroke Clinical Trials Network Ireland, Dublin, Ireland (P.J.K., S.G., P.S., J.J.M.).
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Dipender Gill, BMBCh, PhD https://orcid.org/0000-0001-7312-7078
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK (D.G.).
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Martin Dichgans, MD https://orcid.org/0000-0002-0654-387X
Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany (M.D., M.K.G.).
German Center for Neurodegenerative Disease, Munich, Germany (M.D.).
Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.).
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Marios K. Georgakis, PhD https://orcid.org/0000-0003-3507-3659
Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany (M.D., M.K.G.).
Center for Genomic Medicine, Massachusetts General Hospital, Boston (M.K.G.).
Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Boston (M.K.G.).
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Marie-Joe Dib, PhD https://orcid.org/0000-0001-7591-5684
Cardiovascular Division, Perelman School for Advanced Medicine, University of Pennsylvania, Philadelphia (M.-J.D.).
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Eloi Gagnon, MA https://orcid.org/0000-0002-7483-1371
Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Canada (E.G.).
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Niall Mahon, MB https://orcid.org/0000-0002-2872-2297
Stroke Service, and Department of Cardiology (N.M., G.J.B.), Mater Misericordiae University Hospital, Dublin, Ireland.
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Gavin J. Blake, MB
Stroke Service, and Department of Cardiology (N.M., G.J.B.), Mater Misericordiae University Hospital, Dublin, Ireland.
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Christina Jern, PhD https://orcid.org/0000-0002-7531-2354
Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden (C.J.).
Department of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Sweden (C.J.).
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Hugh S. Markus, PhD https://orcid.org/0000-0002-9794-5996
Stroke Research Group, Department of Clinical Neuroscience, University of Cambridge, UK (H.S.M.).
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William Whiteley, PhD https://orcid.org/0000-0002-4816-8991
Nuffield Department of Population Health, University of Oxford, UK (W.W.).
Centre for Clinical Brain Sciences, University of Edinburgh, UK (W.W.).
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John J. McCabe, PhD https://orcid.org/0000-0003-2029-1303
Geriatric Medicine (J.J.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
Health Research Board, Stroke Clinical Trials Network Ireland, Dublin, Ireland (P.J.K., S.G., P.S., J.J.M.).
School of Medicine, University College Dublin, Ireland (P.J.K., J.J.M.).
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Notes

For Sources of Funding and Disclosures, see page 336.
Circulation is available at www.ahajournals.org/journal/circ
Correspondence to: Stephen Brennan, MB, Stroke Service, Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland. Email [email protected]

Disclosures

None.

Sources of Funding

Dr Kelly has received funding from the Irish Health Research Board. Dr Gill is supported by the British Heart Foundation Centre of Research Excellence (RE/18/4/34215) at Imperial College London.

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Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study
Circulation
  • Vol. 151
  • No. 5

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  • No. 5
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