Association of Breakfast Intake With Incident Stroke and Coronary Heart Disease: The Japan Public Health Center–Based Study
Abstract
Background and Purpose—
The association between breakfast intake and the risk of cardiovascular disease, including stroke, among Asian people remains unknown. We sought to prospectively investigate whether the omission of breakfast is related to increased risks of stroke and coronary heart disease in general Japanese populations.
Methods—
A total of 82 772 participants (38 676 men and 44 096 women) aged 45 to 74 years without histories of cardiovascular disease or cancer were followed up from 1995 to 2010. Participants were classified as having breakfast 0 to 2, 3 to 4, 5 to 6, or 7 times/wk. The hazard ratios of cardiovascular disease were estimated using Cox proportional hazards models.
Results—
During the 1 050 030 person-years of follow-up, we documented a total of 4642 incident cases, 3772 strokes (1051 cerebral hemorrhages, 417 subarachnoid hemorrhages, and 2286 cerebral infarctions), and 870 coronary heart disease. Multivariable analysis showed that those consuming no breakfast per week compared with those consuming breakfast everyday had hazard ratios (95% confidence interval; P for trend) of 1.14 (1.01–1.27; 0.013) for total cardiovascular disease, 1.18 (1.04–1.34; 0.007) for total stroke, and 1.36 (1.10–1.70; 0.004) for cerebral hemorrhage. Similar results were observed even after exclusion of early cardiovascular events. No significant association between the frequency of breakfast intake and the risk of coronary heart disease was observed.
Conclusions—
The frequency of breakfast intake was inversely associated with the risk of stroke, especially cerebral hemorrhage in Japanese, suggesting that eating breakfast everyday may be beneficial for the prevention of stroke.
Introduction
Several previous reports from not only Western but also Asian countries have shown that the omission of breakfast has been associated with a higher prevalence of obesity,1–3 hypertension,2,4 dyslipidemia,1,4,5 glucose intolerance,1,2,5–8 which are well-known risk factors of cardiovascular disease (CVD). Therefore, skipping breakfast is expected to increase the risk of CVD through impaired health conditions, such as hypertension and diabetes mellitus (mediators).
However, no guidelines in the world have to date recommended adults to eat breakfast everyday to prevent CVD because there is not enough evidence to support the beneficial effect by eating breakfast on CVD. To the best of our knowledge, only 1 study showed that eating breakfast was associated with a lower risk of coronary heart disease (CHD) in a cohort of male US health professionals,9 and the association between breakfast intake and the risk of CVD, including stroke, among other races such as Asian populations remains unknown. If we also find that eating breakfast is associated with a reduced risk of CVD among Asian people, whose eating habits are different from those of Western people, the reduced risk of CVD associated with breakfast could be caused by not only cardiovascular protective diets such as high cereal fiber intake at breakfast10 but also the consumption of breakfast itself. As a result, it might be well grounded to recommend that people worldwide eat breakfast, regardless of its contents.
The objective of this study was to prospectively investigate whether the omission of breakfast is related to increased risks of stroke and CHD in general Japanese populations.
Methods
Study Population
The Japan Public Health Center–Based Prospective (JPHC) study is an ongoing prospective study comprising a population-based sample of 140 420 Japanese adults (68 722 men and 71 698 women) aged 40 to 69 years. However, because participants in Tokyo and Osaka were excluded from the study because of unavailable of incidence data, only 116 896 subjects were eligible for follow-up (additional details are available in the online-only Data Supplement).
The questionnaire on breakfast was added to the second survey (1995 [cohort I] and 1998 [cohort II]). Of 116 896 subjects, 3053 subjects were excluded from the present study because they were identified as having died, moved out of the study area, or been lost at the second survey. Therefore, a total of 113 393 patients from the 2 cohorts were eligible for participation in the present study, and the second survey was considered as the baseline for this study. Of 113 393 participants, 88 981 participants (78%) completed the questionnaires, including information on breakfast at the second survey. In addition, we excluded 6209 patients who had a history of stroke, myocardial infarction, angina pectoris, or cancer at the baseline. Ultimately, a total of 82 772 participants (38 676 men and 44 096 women) were included in the present study. The institutional human ethics review boards of Osaka University and the National Cancer Center approved the present study.
Main Exposure: Frequency of Breakfast Intake
Participants were asked to provide information concerning the average frequency of breakfast consumption as follows: “How often do you have breakfast a week? Almost never, 1 to 3 times per month, 1 to 2, 3 to 4, 5 to 6 times per week, or everyday.” In the current study, subjects were classified into the following 4 groups for comparison: those who had breakfast 0 to 2 (subjects with almost never, those with 1–3 times/mo, and those with 1–2 times/wk were combined because of the small number of those with 1–3 times/mo or 1–2 times/wk), 3–4, 5–6, or 7 (those with everyday) times/wk. Those who had breakfast 7 times/wk were regarded as the reference group.
Potential Confounding Factors
Potential confounding factors included age, sex, body mass index (quintile), use of medication for hypertension, hypercholesterolemia, and diabetes mellitus (yes or no), history of diabetes mellitus (yes or no), smoking status (never, ex-smoker, or current smoker), regular leisure-time sports or physical exercise (<1 or ≥1 time/wk), sleep duration (6–8 or either <6 or >8 hours/d),11–13 perceived mental stress (low, medium, or high), living alone (yes or no), physical labor (yes or no: yes means agriculture, forestry or fishery; no means salaried, self-employed, professional, housework, retired, or unemployed), and public health center areas, alcohol intake (0, 1–150, 150–300, ≥301 g/wk), quintiles of total energy intake, vegetables, fruits, fish, soy, milk/dairy products, nuts, saturated fatty acids, dietary fiber, and sodium. Intakes of these foods and nutrients were adjusted for energy intake using the nutrient residual model (additional details are available in the online-only Data Supplement).14
Confirmation of Stroke and CHD
Strokes or myocardial infarction was confirmed according to the criteria of the National Survey of Stroke15 or the Monitoring Trends and Determinants of Cardiovascular Disease project,16 respectively. CHD was defined as myocardial infarction and sudden cardiac death (additional details are available in the online-only Data Supplement).
Statistical Analysis
The person-years of follow-up for each participant were calculated from the baseline to the first end point: cardiovascular event, death, a move from the community, or the end of the follow-up (2009 for cohort I and 2010 for cohort II; additional details are available in the online-only Data Supplement). Age, sex-adjusted mean values, and prevalence of selected factors were calculated and compared among the 4 groups using linear or logistic regression analysis, respectively. Hazard ratios and their 95% confidence intervals for each outcome were calculated using Cox proportional hazard models. Because obesity, hypertension, hypercholesterolemia, and diabetes mellitus could be mediators of the association between breakfast and CVD risk,9 we did not include body mass index, medication for hypertension, hypercholesterolemia, and diabetes mellitus, and a history of diabetes mellitus in the adjustment. Actual blood pressure or plasma levels of cholesterol were only available for 29% of total participants (8598 men and 15 695 women). SAS version 9.4 software (SAS Institute Inc, Cary, NC) was used for statistical analyses. All statistical tests were 2 tailed, and P<0.05 were regarded as significant.
Results
Table 1 lists the baseline characteristics according to the frequency of breakfast intake. Age, sex, diet factors, lifestyle factors, and potential mediators at baseline were almost all significantly correlated with the frequency of breakfast intake.
Frequency of Breakfast Intake, Times/wk | 0–2 | 3–4 | 5–6 | 7 | P Value |
---|---|---|---|---|---|
Number at risk | 6759 | 2687 | 2788 | 70 538 | … |
Age, y* | 53.4 | 53.1 | 53.4 | 57.1 | <0.001 |
Men, %† | 49.2 | 44.3 | 47.7 | 46.5 | 0.002 |
Diet factors‡ | |||||
Current drinker, % | 47.5 | 47.4 | 47.7 | 44.6 | <0.001 |
Mean energy intake, kcal/d | 1863 | 1956 | 1982 | 2091 | <0.001 |
Vegetable intake, g/d | 213 | 219 | 218 | 228 | <0.001 |
Fruits intake, g/d | 196 | 202 | 205 | 225 | <0.001 |
Fish intake, g/d | 86.7 | 86.5 | 87.2 | 94.0 | <0.001 |
Milk/dairy products intake, g/d | 161 | 170 | 180 | 188 | <0.001 |
Soy intake, g/d | 86.5 | 92.3 | 87.3 | 94.9 | <0.001 |
Nuts intake, g/d | 1.8 | 1.8 | 1.7 | 2.0 | <0.001 |
Saturated fatty acid intake, g/d | 18.7 | 18.3 | 18.0 | 17.1 | <0.001 |
Dietary fiber intake, g/d | 11.8 | 12.3 | 12.3 | 13.6 | <0.001 |
Sodium intake, mg/d | 4738 | 4742 | 4755 | 5040 | <0.001 |
Lifestyle factors, % | |||||
Current smoker | 37.7 | 30.9 | 29.9 | 23.4 | <0.001 |
Leisure-time sports ≥1 time/wk | 18.8 | 23.3 | 21.0 | 20.7 | 0.033 |
Sleep duration 6–8 h/d | 83.8 | 84.7 | 86.2 | 87.9 | <0.001 |
High perceived mental stress | 21.0 | 20.1 | 22.1 | 17.1 | <0.001 |
Living alone | 10.2 | 10.1 | 8.8 | 4.4 | <0.001 |
Physical labor | 16.2 | 17.4 | 19.8 | 27.6 | <0.001 |
Potential mediators, % | |||||
Body mass index ≥25 kg/m2 | 31.2 | 32.6 | 28.6 | 28.0 | <0.001 |
High blood pressure§ | 35.2 | 35.9 | 32.8 | 33.1 | 0.096 |
Medication use for hypertension | 16.9 | 17.1 | 16.2 | 19.4 | <0.001 |
High total cholesterol§ | 40.5 | 33.5 | 35.4 | 33.8 | <0.001 |
Medication use for hypercholesterolemia | 4.0 | 4.2 | 4.2 | 5.1 | <0.001 |
Diabetes mellitus | 3.2 | 3.7 | 3.8 | 4.7 | <0.001 |
Medication use for diabetes mellitus | 2.2 | 2.5 | 2.3 | 3.0 | <0.001 |
*
Sex-adjusted mean.
†
Age-adjusted mean.
‡
Age-, sex-, and energy-adjusted mean.
§
Only available for subsample (8598 men and 15 695 women). High blood pressure: systolic blood pressure ≥140 or diastolic blood pressure ≥90 mm Hg. High cholesterol: total cholesterol ≥220 mg/dL.
During the 1 050 030 person-years of follow-up of 82 772 participants, we documented a total of 4642 incident cases of CVD, 3772 strokes, including 1051 cerebral hemorrhages, 417 subarachnoid hemorrhages, and 2286 cerebral infarctions, and 870 CHD (Table 2). A total of 5839 participants (7%) had been lost to follow-up for 15 years. Age- and sex-adjusted analysis showed that the frequency of breakfast intake was inversely associated with risks of total CVD, total stroke, and cerebral hemorrhage. Further adjustment for diet factors, lifestyle factors, and public health area attenuated the associations, but the associations remained significant. Finally, those who had no breakfast had hazard ratios (95% confidence interval; P for trend) of 1.14 (1.01–1.27; 0.013) for total CVD, 1.18 (1.04–1.34; 0.007) for total stroke, and 1.36 (1.10–1.70; 0.004) for cerebral hemorrhage.
Frequency of Breakfast Intake, Times/wk | 0–2 | 3–4 | 5–6 | 7 | P for Trend |
---|---|---|---|---|---|
Person-years | 84 513 | 33 954 | 35 169 | 896 395 | |
Total cardiovascular disease, n | 360 | 132 | 123 | 4027 | |
Age- and sex-adjusted HR (95% CI) | 1.22 (1.10–1.36) | 1.19 (1.00–1.42) | 1.01 (0.85–1.21) | 1.00 | <0.001 |
+ Diet factors* | 1.16 (1.03–1.29) | 1.16 (0.97–1.38) | 0.98 (0.82–1.18) | 1.00 | 0.005 |
+ Lifestyle factors and public health area† | 1.14 (1.01–1.27) | 1.17 (0.98–1.39) | 0.99 (0.83–1.19) | 1.00 | 0.013 |
Total stroke, n | 294 | 103 | 100 | 3275 | |
Age- and sex-adjusted HR (95% CI) | 1.23 (1.09–1.39) | 1.14 (0.94–1.39) | 1.01 (0.83–1.23) | 1.00 | <0.001 |
+ Diet factors* | 1.18 (1.04–1.33) | 1.11 (0.91–1.36) | 0.98 (0.80–1.20) | 1.00 | 0.008 |
+ Lifestyle factors and public health area† | 1.18 (1.04–1.34) | 1.14 (0.93–1.39) | 1.00 (0.82–1.22) | 1.00 | 0.007 |
Cerebral hemorrhage, n | 101 | 34 | 33 | 883 | |
Age- and sex-adjusted HR (95% CI) | 1.48 (1.20–1.82) | 1.31 (0.93–1.84) | 1.17 (0.83–1.66) | 1.00 | <0.001 |
+ Diet factors* | 1.39 (1.12–1.72) | 1.24 (0.87–1.75) | 1.12 (0.79–1.59) | 1.00 | 0.002 |
+ Lifestyle factors and public health area† | 1.36 (1.10–1.70) | 1.22 (0.86–1.73) | 1.10 (0.77–1.56) | 1.00 | 0.004 |
Subarachnoid hemorrhage, n | 34 | 11 | 8 | 364 | |
Age- and sex-adjusted HR (95% CI) | 1.09 (0.77–1.56) | 0.87 (0.48–1.59) | 0.61 (0.30–1.24) | 1.00 | 0.918 |
+ Diet factors* | 1.11 (0.77–1.60) | 0.89 (0.49–1.63) | 0.63 (0.31–1.26) | 1.00 | 0.821 |
+ Lifestyle factors and public health area† | 1.10 (0.76–1.60) | 0.94 (0.51–1.72) | 0.66 (0.32–1.33) | 1.00 | 0.801 |
Cerebral infarction, n | 158 | 57 | 59 | 2012 | |
Age- and sex-adjusted HR (95% CI) | 1.14 (0.97–1.34) | 1.11 (0.85–1.45) | 1.03 (0.79–1.33) | 1.00 | 0.089 |
+ Diet factors* | 1.09 (0.92–1.28) | 1.09 (0.83–1.42) | 1.00 (0.77–1.30) | 1.00 | 0.287 |
+ Lifestyle factors and public health area† | 1.10 (0.92–1.30) | 1.13 (0.86–1.47) | 1.03 (0.79–1.33) | 1.00 | 0.217 |
Coronary heart disease, n | 66 | 29 | 23 | 752 | |
Age- and sex-adjusted HR (95% CI) | 1.19 (0.92–1.53) | 1.43 (0.98–2.08) | 1.01 (0.67–1.54) | 1.00 | 0.066 |
+ Diet factors* | 1.05 (0.81–1.37) | 1.34 (0.92–1.95) | 0.96 (0.63–1.46) | 1.00 | 0.419 |
+ Lifestyle factors and public health area† | 0.96 (0.73–1.25) | 1.27 (0.87–1.85) | 0.95 (0.62–1.44) | 1.00 | 0.974 |
CI indicates confidence interval; and HR, hazard ratio.
*
Further adjusted for ethanol, energy, vegetables, fruits, fish, soy, milk/dairy products, nuts, saturated fatty acid, dietary fiber and sodium intake.
†
Further adjusted for smoking status, leisure-time sports, sleep duration, perceived mental stress, living alone, physical labor, and public health center area.
We stratified participants by medication use for hypertension (potential mediator), which is major risk factor for stroke, especially cerebral hemorrhage (Table I in the online-only Data Supplement). Trends similar to the results in Table 2 were observed among antihypertensive medication nonusers. On the contrary, among antihypertensive medication users, the frequency of breakfast intake was associated with risks of only total CVD, but not of total stroke or cerebral hemorrhage.
In addition, to examine the potential reverse causation for the frequency of breakfast intake and the risk of CVD, we repeated our analyses of the associations when early cardiovascular events (≤5 years from the baseline) were excluded. These associations were similar after the exclusion (Table II in the online-only Data Supplement).
Discussion
We observed inverse associations between the frequency of breakfast intake and the risks of total CVD, total stroke, and cerebral hemorrhage, but not of CHD, in this prospective cohort study of Japanese people. To the best of our knowledge, this is the first study to investigate the associations of breakfast intake frequency with cardiovascular events that include not only CHD but also stroke and its subtypes in an Asian population.
The major risk factor of cerebral hemorrhage is hypertension, especially an increase in blood pressure in the morning (a morning blood pressure surge).17 In the current study, those having breakfast everyday were not significantly but less likely to have high blood pressure (systolic blood pressure ≥140 or diastolic blood pressure ≥90 mm Hg) than those skipping breakfast although they were from the subsample. Several previous studies have shown that cerebral hemorrhage occurs more frequently in the morning than during the remainder of the day.18–20 Therefore, it may be important to reduce the frequency or duration of high blood pressure in the morning to prevent cerebral hemorrhage, and eating breakfast everyday might achieve this. Witbracht et al21 suggested that skipping breakfast was associated with stress-independent overactivity in the hypothalamic–pituitary–adrenal axis because of a longer period of fasting, leading to elevated blood pressure in the morning. In addition, Ahuja et al22 reported that men and women aged 21–80 years old showed a rapid decrease in systolic and diastolic blood pressure after having breakfast in a randomized cross-over design. Other than these 2 studies, there are several previous reports on a blood pressure reduction by breakfast intake.23–25 This effect of breakfast intake on blood pressure in the morning might be one of the mechanisms of the result from the present study.
Because we considered hypertension as a major mediator between breakfast intake and stroke, especially cerebral hemorrhage, we conducted further analyses after stratification by medication use of hypertension. We found the associations among antihypertensive medication nonusers similar to those among total participants. Even if those having no breakfast were not diagnosed with hypertension at baseline, they might have developed hypertension through skipping breakfast during the follow-up. In addition, breakfast skippers who had mild hypertension but did not clinically need to take medication at baseline might have had a morning blood pressure surge. In contrast, among antihypertensive medication users, those skipping breakfast had higher risk of total CVD, but not of cerebral hemorrhage. This result suggests beneficial effects of having breakfast on health condition (body weight, lipid metabolism, etc) other than blood pressure.
Although the previous study showed the significant association between the frequency of breakfast and the risk of CHD,9 our study did not. In Japan, historically, the prevalence of CHD has been lower than in Western countries because of the lower prevalence of hypercholesterolemia,26 and on the contrary, the prevalence of stroke, especially cerebral hemorrhage, has been higher because of the higher prevalence of hypertension.27,28 In the current study, we also observed the small number of CHD incidence when compared with the previous study,9 and as a result the statistical power was low. We did not find the significant association between the frequency of breakfast intake and the risk of subarachnoid hemorrhage probably because of the low statistical power, either. On the contrary, although a large number of incident cases of cerebral infarction were documented, the frequency of breakfast intake was not inversely associated with the risk of cerebral infarction. Metoki et al17 reported that the morning pressure surge was associated with the risk of cerebral hemorrhage, which was not associated with the risk of cerebral infarction. Therefore, to reduce the risk of the morning pressure surge by eating breakfast might not lead to the prevention of cerebral infarction.
Elevated risks of CVD could make it difficult for people to have breakfast (reverse causation). For example, hypertensive people often have hypertension-attributed symptoms such as headache and dizziness in the morning.29 In the current study, however, the analyses with the early cardiovascular events excluded did not substantially change the associations of breakfast intake frequency with the risk of total CVD, total stroke, and cerebral hemorrhage.
In the current study, the frequency of breakfast intake was inversely associated with the prevalence of participants with body mass index ≥25 kg/m2, whereas it was positively associated with the prevalence of diabetes mellitus. Although these associations seem incompatible, our baseline survey might reflect that after breakfast skippers were diagnosed with diabetes mellitus, they might have changed their unhealthy lifestyle, leading to loss of body weight, and started to eat breakfast to take medicines for diabetes mellitus before the baseline survey.
The strengths of our study include its prospective design, the long follow-up duration, its inclusion of a large sample from the general population, a variety of end points including stroke subtypes, and the high availability of computed tomography/magnetic resonance imaging for stroke diagnosis. To recommend that people in general should have breakfast, this study focused on the general population and yielded results that are more relevant than those on occupational or hospital-based volunteers, who often work night shifts. Finally, the detailed information on the frequency of breakfast intake enabled us to show that the more often people omit eating breakfast, the higher the risk of CVD they would have.
Nonetheless, some limitations do need to be addressed. First, the information on the frequency of breakfast intake was obtained only at baseline. Therefore, it is possible that participants might have changed their eating habits during the follow-up. Second, the data on participants’ actual blood pressure or plasma levels of cholesterol were only available for 29% of total participants. Because high blood pressure is an important predictor for cerebral hemorrhage, a further study will need to include actual blood pressure for all participants to clarify the underlying mechanism. Third, because breakfast skippers are likely to lead an unhealthy lifestyle such as smoking4,30 and might have lower intakes of healthy foods such as dietary fiber and fruits than breakfast eaters; eating breakfast could also be considered as a behavioral marker for healthy lifestyle. Although we still observed a significant inverse association between the frequency of breakfast intake and the risk of cerebral hemorrhage even after adjusting for various kinds of diet and lifestyle factors, we cannot negate the possibility of residual confounding or an unmeasured third variable (eg, level of education).
In conclusion, we found in a large, prospective cohort study of Japanese populations that the frequency of breakfast intake was inversely associated with the risk of stroke, especially cerebral hemorrhage. Our results suggest that eating breakfast everyday may be beneficial for the prevention of stroke.
Acknowledgments
We thank all staff members involved in this study for their valuable help in conducting the baseline survey and follow-up.
Supplemental Material
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The image is taken from an article in this issue, “Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease” by Ihara and Yamamoto (Stroke. 2016;47:554–560).
The image is Figure 1.
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© 2016 American Heart Association, Inc.
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History
Received: 28 August 2015
Revision received: 18 November 2015
Accepted: 30 November 2015
Published online: 5 January 2016
Published in print: February 2016
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Sources of Funding
This study was supported by Grants-in-Aid for the Third Term Comprehensive Ten-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan, as well as by National Cancer Center Research and Development Fund (23-A-31[toku] and 26-A-2; since 2011) and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (from 1989 to 2010).
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- The influence of meal frequency and meal timing on cardiometabolic health, Health Care Academician Journal, 11, 4, (639-645), (2024).https://doi.org/10.52880/sagakaderg.1568901
- The Association between the Planetary Health Diet with a Regular Consumption of Breakfast and a Well-Balanced Diet: A Cross-Sectional Analysis Involving Japanese Male Engineering Students at a University in Hyogo Prefecture, International Journal of Environmental Research and Public Health, 21, 7, (858), (2024).https://doi.org/10.3390/ijerph21070858
- Effect of Cereal Consumption (Frugra®) on Autonomic Nervous System Function in Healthcare Workers Who Skip Breakfast, Journal of Nutritional Science and Vitaminology, 70, 5, (380-386), (2024).https://doi.org/10.3177/jnsv.70.380
- Breakfast skipping and risk of all-cause, cardiovascular and cancer mortality among adults: a systematic review and meta-analysis of prospective cohort studies, Food & Function, 15, 11, (5703-5713), (2024).https://doi.org/10.1039/D3FO05705D
- Determinants of breakfast skipping among pregnant women from South Ethiopia Gamo Zone: a case-control study, Scientific Reports, 14, 1, (2024).https://doi.org/10.1038/s41598-024-73467-9
- Breakfast skipping and traits of cardiometabolic health: A mendelian randomization study, Clinical Nutrition ESPEN, 59, (328-333), (2024).https://doi.org/10.1016/j.clnesp.2023.12.149
- A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense, Cell, 187, 22, (6251-6271.e20), (2024).https://doi.org/10.1016/j.cell.2024.08.012
- Small Dense Low-Density Lipoprotein Cholesterol Levels in Breakfast Skippers and Staple Foods Skippers, Journal of Atherosclerosis and Thrombosis, 30, 10, (1376-1388), (2023).https://doi.org/10.5551/jat.64024
- Breakfast Type and Cardiovascular Mortality: The Japan Collaborative Cohort Study, Journal of Atherosclerosis and Thrombosis, 30, 9, (1255-1264), (2023).https://doi.org/10.5551/jat.63564
- The association of energy and macronutrient intake at breakfast and cardiovascular disease in Chinese adults: From a 14-year follow-up cohort study, Frontiers in Nutrition, 10, (2023).https://doi.org/10.3389/fnut.2023.1093561
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