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Some Effects of Digoxin on the Heart and Circulation in Man

Digoxin in Enlarged Hearts Not in Clinical Congestive Failure
Originally publishedhttps://doi.org/10.1161/01.CIR.4.3.366Circulation. 1951;4:366–377

    The early effect of intravenous Digoxin was observed in 12 patients with cardiac enlargement in whom there was no clinical or physiologic evidence of failure. There was either a fall or no change in the cardiac output and the intracardiac pressures did not alter following administration of the drug. The reaction to Digoxin in this type of patient with heart disease was in no way different from the response seen in two normal subjects included in the study but is in sharp contrast to the response elicited in patients in congestive heart failure.

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