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Core 2. Epidemiology and Prevention of CV Disease: Physiology, Pharmacology and Lifestyle
Session Title: CVD, Risk Factors and Trends in Populations

Abstract 16854: Iodine Deficiency and Risk of Coronary Heart Disease Events Among Low Risk Healthy US Adults

Originally publishedCirculation. 2011;124:A16854

    Background: Prevalence of iodine deficiency (ID) has increased among general US population. No study has evaluated ID's effect on primary risk of coronary heart disease (CHD) events.

    Objective: Evaluate the relationship between ID and CHD risk

    Design: Cross-sectional

    Methods: We evaluated 10,037 adults, free of cardiovascular disease and diabetes, participating in National Health and Nutrition Examination Surveys . Participants were assigned Framingham risk score (FRS) per Adult Treatment Plan guidelines. Urine iodine levels (mcg/L) were used to define ID per World Health Organization criteria: Group 1 -: None(≥100), Group 2 -: Mild(50-99) and Group 3 -: Moderate-severe(<50). Multivariate regression analysis was performed to analyze the effect of ID on the risk of having higher FRS.

    Results: Mean FRS increased with higher degrees of ID (Group 1: 7.5±8.1 vs Group 3: 9.4±7.4, p<0.001). ID significantly predicted (p<0.001) higher FRS after adjusting for race, body mass index, history of thyroid dysfunction, hemoglobin A1c, high sensitivity C-reactive protein, estimated glomerular filtration rate, serum T4, serum thyroid stimulating hormone and selenium levels [beta co-efficient 0.69(95% confidence interval (CI):0.38-1.00) for group 2 and 1.46(95% CI:1.08-1.84) for group 3 compared to group 1]. Similar results were observed when FRS was evaluated in categories. (Table 1)

    Conclusion: ID is associated with CHD risk independent of thyroid dysfunction and traditional cardiovascular risk factors. Further validation of our study results is warranted since ID is easily remediable through public health policies.


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