Poster Abstract Presentations
Session Title: Clinical, Genetic and Epidemiological Mechanisms
Abstract P2071: β-1,3/1,6-d-glucan Of Indonesian Ganoderma Lucidum Mycelium Extract Reduces Systolic Blood Pressure & Inflammation In Hypertensive Patients
Background: Extract of Ganodermalucidum Mycelium containing β-1,3/1,6-D-Glucan has shown to possess beneficial effects on cardiovascular diseases.
Objective: To examine the effectiveness of β-1,3/1,6-D-Glucan (GLME) consumption to reduced blood pressure (BP) & inflammation in patients with hypertension.
Material and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 50 hypertensive adults (JNC VII, age 50-70 years). The patients were divided into 6 groups. Group A: received GLME 540mg/day + CCB, Group B: GLME + ACEI/ARB, Group C: placebo + ACEI, Group D: placebo + CCB, Group E: GLME only & Group F: placebo only. We used the Morisky score to evaluate treatment’s adherence & excludes patients with Morisky < 6. A standardized method was used to measure BP at baseline and thereafter every 30 days until day 90. Further, heart rate (HR), LVEF, LVMI, hsCRP, MDA, TNF-α, IL-1, & IL-6 were measured at baseline & at 90-days.
Results: At day 90, GLME lowered systolic BP (SBP) compared to placebo (–22.82±11.4 vs. –10±16.0 mmHg; p= 0.007), DBP was lowered without significant difference between GLME & placebo groups. The change in mean arterial pressure was significance compared with placebo p= 0.028. Group B have the most reducing SBP effect compared with others, p=0.000. The reducing effect of mean arterial pressure was significance in group A compared with others, p= 0.008. In Group B, we found that there was a significance decreasing in hsCRP compared with p=0.01. The reducing effect LVMI, TNF-α, plasma IL- 6 and IL-1 concentration was significantly lower in group B compared with other group (p= 0.043, p= 0.001, p= 0.0008, p= 0.0005, respectively).
Conclusion: GLME may significantly reduce SBP systolic & LVMI & may have an anti-inflammatory effect shown through the reduction of IL-6, IL-1β, and TNF-α.