Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults
- Daniel H. Katz ,
- Usman A. Tahir ,
- Debby Ngo ,
- Mark D. Benson ,
- Yan Gao ,
- Xu Shi ,
- Matthew Nayor ,
- Michelle J. Keyes ,
- Martin G. Larson ,
- Michael E. Hall ,
- Adolfo Correa ,
- Sumita Sinha ,
- Dongxiao Shen ,
- Matthew Herzig ,
- Qiong Yang ,
- Jeremy M. Robbins ,
- Zsu-Zsu Chen ,
- Daniel E. Cruz ,
- Bennet Peterson ,
- Ramachandran S. Vasan ,
- Thomas J. Wang ,
- James G. Wilson and
- Robert E. Gerszten
https://orcid.org/0000-0001-7237-8502
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
https://orcid.org/0000-0003-2681-3475
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
Department of Medicine, University of Mississippi Medical Center, Jackson, MS (Y.G., M.E.H., A.C.).
https://orcid.org/0000-0002-9473-0359
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
https://orcid.org/0000-0002-6993-9396
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (M.N.).
https://orcid.org/0000-0003-0303-1390
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
Framingham Heart Study, MA (M.J.K., M.G.L., R.S.V.).
Framingham Heart Study, MA (M.J.K., M.G.L., R.S.V.).
Deptartment of Biostatistics, Boston University School of Public Health, Boston, MA (M.G.L.)
https://orcid.org/0000-0002-5733-1025
Department of Medicine, University of Mississippi Medical Center, Jackson, MS (Y.G., M.E.H., A.C.).
https://orcid.org/0000-0002-9501-600X
Department of Medicine, University of Mississippi Medical Center, Jackson, MS (Y.G., M.E.H., A.C.).
Whitehead Institute for Biomedical Research, Cambridge, MA (S.S.).
https://orcid.org/0000-0003-4164-0402
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
https://orcid.org/0000-0002-1915-2915
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
https://orcid.org/0000-0002-3658-1375
Department of Biostatistics, Boston University School of Public Health, MA (Q.Y.).
https://orcid.org/0000-0001-9441-675X
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
https://orcid.org/0000-0001-9441-675X
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
https://orcid.org/0000-0001-7906-5146
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
https://orcid.org/0000-0001-7357-5970
Framingham Heart Study, MA (M.J.K., M.G.L., R.S.V.).
https://orcid.org/0000-0003-4063-6508
Department of Medicine, UT Southwestern Medical Center, Dallas, TX (T.J.W.).
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
Correspondence to: Robert E. Gerszten, MD, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Baker 408, Boston, MA 02215. Email
E-mail Address: [email protected]
https://orcid.org/0000-0002-6767-7687
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., X.S., M.J.K., D.S., M.H., J.M.R., Z.-Z.C., D.E.C., B.P., J.G.W., R.E.G.).
Broad Institute of Harvard and MIT, Cambridge, MA (R.E.G.).
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