Table Of Contents Page
AHA Volume 51, Number 5
On the cover: Structure-based identification of an ACE2 activator. (A) Free (open) and inhibitor bound (closed) ACE2 structures (PDBID: 1R42 and 1R4L, respectively). Secondary structure is shown in red for helices, gray for loops, and gold for strands. (B) Sphere clusters targeting 3 sites on ACE2. Spheres are in yellow, and secondary structure is shown as in A. B shows the structure of the inhibitor-bound conformation of ACE2 (inhibitor not shown). The cluster for site 1 was generated based on the structure of the open form of the enzyme, but it is shown superposed on the closed form to show its relative position to the other clusters. The view of the structure rotated 90° around the horizontal axis. (See page 1312.)
